What is your favorite setting or ruleset to make a character in? Is this different from your favorite one to play in? What about as a DM?
I think my favorite setting to run a game in is probably the World of Darkness for the White Wolf games, with an emphasis on chronicles taking place in the 21st century. It is at once like and unlike our own world. For a few months I had a Werewolf: Wild West game that was very popular and timely, as half the group was, at that time, taking a pre-Civil War US history class and AMC's show Hell on Wheels had just premiered. But I still think playing in the real world in a contemporary period, preferably set in the same town you actually live in, makes it easier for the players to relate to.
My favorite game as a player is probably anything in the fantasy genre. I've played in Pathfinder so much in the last few years that I can't imagine switching to 4E or 5E or going back to D&D.